Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050414-07
Application #
2093761
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1989-07-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Hurshman, Amy R; Krebs, Carsten; Edmondson, Dale E et al. (2003) Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. Biochemistry 42:13287-303
Hurshman, Amy R; Marletta, Michael A (2002) Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer. Biochemistry 41:3439-56
Huang, H; Martasek, P; Roman, L J et al. (2001) Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase. J Enzyme Inhib 16:233-9
Huang, H; Martasek, P; Roman, L J et al. (2000) Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. J Med Chem 43:2938-45
Perry, J M; Zhao, Y; Marletta, M A (2000) Cu2+ and Zn2+ inhibit nitric-oxide synthase through an interaction with the reductase domain. J Biol Chem 275:14070-6
Lee, Y; Marletta, M A; Martasek, P et al. (1999) Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases. Bioorg Med Chem 7:1097-104
Huang, H; Martasek, P; Roman, L J et al. (1999) N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem 42:3147-53
Hurshman, A R; Krebs, C; Edmondson, D E et al. (1999) Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. Biochemistry 38:15689-96
Cordelier, P; Esteve, J P; Rivard, N et al. (1999) The activation of neuronal NO synthase is mediated by G-protein betagamma subunit and the tyrosine phosphatase SHP-2. FASEB J 13:2037-50
Rusche, K M; Spiering, M M; Marletta, M A (1998) Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase. Biochemistry 37:15503-12

Showing the most recent 10 out of 35 publications