Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA053191-04
Application #
2095238
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1991-07-15
Project End
1997-06-30
Budget Start
1994-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Cvrk, T; Strobel, H W (2001) Role of THR501 residue in substrate binding and catalytic activity of cytochrome P4501A1. Arch Biochem Biophys 389:31-40
Cvrk, T; Strobel, H W (2001) Role of LYS271 and LYS279 residues in the interaction of cytochrome P4501A1 with NADPH-cytochrome P450 reductase. Arch Biochem Biophys 385:290-300
Cvrk, T; Strobel, H W (1998) Photoaffinity labeling of cytochrome P4501A1 with azidocumene: identification of cumene hydroperoxide binding region. Arch Biochem Biophys 349:95-104
Yu, X C; Strobel, H W (1997) Hydroperoxide-mediated cytochrome P450-dependent 8-anilino-1-naphthalenesulfonic acid destruction, product formation and P450 modification. Mol Cell Biochem 167:159-68
Hodgson, A V; Strobel, H W (1996) Quantitation of FAD-dependent cytochrome P450 reductase activity by photoreduction. Anal Biochem 243:154-7
Yu, X C; Strobel, H W (1996) Interactions of 8-anilino-1-naphthalenesulfonic acid (ANS) and cytochrome P450 2B1: role of ANS as an effector as well as a reporter group. Mol Cell Biochem 162:89-95
Hodgson, A V; Strobel, H W (1996) Characterization of the FAD binding domain of cytochrome P450 reductase. Arch Biochem Biophys 325:99-106
Cvrk, T; Hodek, P; Strobel, H W (1996) Identification and characterization of cytochrome P4501A1 amino acid residues interacting with a radiolabeled photoaffinity diazido-benzphetamine analogue. Arch Biochem Biophys 330:142-52
Yu, X C; Liang, C; Strobel, H W (1996) Kinetics of substrate reaction in the course of hydroperoxide-mediated inactivation of cytochrome P450 1A1. Biochemistry 35:6289-96
Yuan, W; White, T B; White, J W et al. (1995) Relationship between hydrocarbon structure and induction of P450: effect on RNA levels. Xenobiotica 25:9-16

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