Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA053248-03S1
Application #
3198043
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1990-12-12
Project End
1994-06-30
Budget Start
1992-12-31
Budget End
1994-06-30
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Spengler, Mary L; Kennett, Sarah B; Moorefield, K Scott et al. (2005) Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism. Cell Signal 17:153-66
Moorefield, K Scott; Fry, Sarah J; Horowitz, Jonathan M (2004) Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells. J Biol Chem 279:13911-24
Kennett, Sarah B; Moorefield, K Scott; Horowitz, Jonathan M (2002) Sp3 represses gene expression via the titration of promoter-specific transcription factors. J Biol Chem 277:9780-9
Sterner, J M; Dew-Knight, S; Musahl, C et al. (1998) Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Mol Cell Biol 18:2748-57
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Kennett, S B; Udvadia, A J; Horowitz, J M (1997) Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription. Nucleic Acids Res 25:3110-7
Rogers, K T; Higgins, P D; Milla, M M et al. (1996) DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. Proc Natl Acad Sci U S A 93:7594-9
Sterner, J M; Tao, Y; Kennett, S B et al. (1996) The amino terminus of the retinoblastoma (Rb) protein associates with a cyclin-dependent kinase-like kinase via Rb amino acids required for growth suppression. Cell Growth Differ 7:53-64
Sterner, J M; Murata, Y; Kim, H G et al. (1995) Detection of a novel cell cycle-regulated kinase activity that associates with the amino terminus of the retinoblastoma protein in G2/M phases. J Biol Chem 270:9281-8
Udvadia, A J; Templeton, D J; Horowitz, J M (1995) Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression. Proc Natl Acad Sci U S A 92:3953-7

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