Abstract

The Proliferating Cell Nuclear Antigen (PCNA) is the co-factor of DNA polymerase delta, a Key enzyme in cellular DNA synthesis. Is is required for DNA replication and cell cycle progression. Because of the important role that PCNA plays in proliferating cells and because of some unusual aspects in the structure and function of its gene, we propose to investigate the growth-regulation of the PCNA gene, how growth factors affect it and which trans-acting factors interact with its regulatory elements. This project's goal is a better understanding of the factors that regulate cell cycle progression at the G1/S boundary.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA053484-04
Application #
3198197
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1990-12-01
Project End
1995-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Dews, M; Prisco, M; Peruzzi, F et al. (2000) Domains of the insulin-like growth factor I receptor required for the activation of extracellular signal-regulated kinases. Endocrinology 141:1289-300
Reiss, K; Wang, J Y; Romano, G et al. (2000) IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene 19:2687-94
Baffa, R; Reiss, K; El-Gabry, E A et al. (2000) Low serum insulin-like growth factor 1 (IGF-1): a significant association with prostate cancer. Tech Urol 6:236-9
Gatzka, M; Prisco, M; Baserga, R (2000) Stabilization of the Ras oncoprotein by the insulin-like growth factor 1 receptor during anchorage-independent growth. Cancer Res 60:4222-30
Morrione, A; Plant, P; Valentinis, B et al. (1999) mGrb10 interacts with Nedd4. J Biol Chem 274:24094-9
Romano, G; Prisco, M; Zanocco-Marani, T et al. (1999) Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling. J Cell Biochem 72:294-310
Valentinis, B; Morrione, A; Peruzzi, F et al. (1999) Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion. Oncogene 18:1827-36
Baserga, R (1999) The IGF-I receptor in cancer research. Exp Cell Res 253:1-6
Zanocco-Marani, T; Bateman, A; Romano, G et al. (1999) Biological activities and signaling pathways of the granulin/epithelin precursor. Cancer Res 59:5331-40
Valentinis, B; Romano, G; Peruzzi, F et al. (1999) Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways. J Biol Chem 274:12423-30

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