Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA054168-04A1
Application #
2095710
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1991-04-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Huang, Xianming; Bennett, Mary; Thorpe, Philip E (2004) Anti-tumor effects and lack of side effects in mice of an immunotoxin directed against human and mouse prostate-specific membrane antigen. Prostate 61:1-11
Mason, Ralph P; Constantinescu, Anca; Ran, Sophia et al. (2003) Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarction. Adv Exp Med Biol 530:197-204
Ran, Sophia; Downes, Amber; Thorpe, Philip E (2002) Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res 62:6132-40
Mason, Ralph P; Ran, Sophia; Thorpe, Philip E (2002) Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiology. J Cell Biochem Suppl 39:45-53
Giatromanolaki, A; Sivridis, E; Athanassou, N et al. (2001) The angiogenic pathway ""vascular endothelial growth factor/flk-1(KDR)-receptor"" in rheumatoid arthritis and osteoarthritis. J Pathol 194:101-8
Brekken, R A; Overholser, J P; Stastny, V A et al. (2000) Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res 60:5117-24
Koukourakis, M I; Giatromanolaki, A; Thorpe, P E et al. (2000) Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer. Cancer Res 60:3088-95
Thorpe, P E; Ran, S (2000) Tumor infarction by targeting tissue factor to tumor vasculature. Cancer J 6 Suppl 3:S237-44
Giatromanolaki, A; Koukourakis, M I; Sivridis, E et al. (2000) Tumor specific activation of the VEGF/KDR angiogenic pathway in a subset of locally advanced squamous cell head and neck carcinomas. Clin Exp Metastasis 18:313-9
Brekken, R A; Huang, X; King, S W et al. (1998) Vascular endothelial growth factor as a marker of tumor endothelium. Cancer Res 58:1952-9

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