Radiation dose-response curves for normal tissues define the probability of injury as a function of effective dose to the tissue. There are very few dose-response curves in the conventional radiation oncology literature and none that have taken account of censoring that results from the death of patients prior to and during the period that late radiation injuries are expressed. The objective of this study is to obtain the dose-response curves for various normal tissues by analyzing outcomes in approximately 440 patients from a single institution who were inadvertently irradiated to doses 10 to 45% in excess of the prescribed doses. In addition, case-control studies will be performed to identify factors other than those that may affect radiation sensitivity. Specifically we propose: 1. To obtain information on the early (severe) and late radiation injuries that resulted from overdoses of 10 to 45%. This information will be obtained from radiotherapy charts, hospital charts, referring physicians, and legal depositions. These overdoses occurred over a 16 month period in a well defined group of 440 patients, and the amount of overdose is approximately evenly distributed among these patients. 2. To perform dose-response analysis using-techniques developed specifically for analyzing late injuries in censored populations. This analysis will be performed for individual organs and tissues for which complications were recorded, and will include fractionation and volume factors. 3. To obtain, from the same sources as in (1), information on factors other than radiation dose that may have influenced the radiation response. These factors include other treatments, previous or concurrent diseases (diabetes mellitus, autoimmune collagen disease, etc.), and physical findings (blood pressure, congenital defects etc.). 4. To perform case-control studies using dose-matched controls to ascertain the significance (relative risk) of factors other than dose in the radiation response.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA054295-04
Application #
2095808
Study Section
Radiation Study Section (RAD)
Project Start
1991-04-01
Project End
1995-03-31
Budget Start
1993-04-01
Budget End
1995-03-31
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Schultheiss, T E; Lee, W R; Hunt, M A et al. (1997) Late GI and GU complications in the treatment of prostate cancer. Int J Radiat Oncol Biol Phys 37:3-11
Kagawa, K; Lee, W R; Schultheiss, T E et al. (1997) Initial clinical assessment of CT-MRI image fusion software in localization of the prostate for 3D conformal radiation therapy. Int J Radiat Oncol Biol Phys 38:319-25
Cohen, L; Schultheiss, T E; Kennaugh, R C (1995) A radiation overdose incident: initial data. Int J Radiat Oncol Biol Phys 33:217-24
Schultheiss, T E; Hanks, G E; Hunt, M A et al. (1995) Incidence of and factors related to late complications in conformal and conventional radiation treatment of cancer of the prostate. Int J Radiat Oncol Biol Phys 32:643-9
Schultheiss, T E; Kun, L E; Ang, K K et al. (1995) Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 31:1093-112
Schultheiss, T E; Stephens, L C; Ang, K K et al. (1994) Volume effects in rhesus monkey spinal cord. Int J Radiat Oncol Biol Phys 29:67-72