The objective of this study is to determine the response of endogenous sex hormones to varying doses of soy derived isoflavonoids in pre- and postmenopausal women. Isoflavonoids have been associated with a number of factors which could result in a decreased incidence and/or progression of breast cancer. One of these factors which has been under investigation in our laboratory is the interaction of these phytoestrogens with the circulating levels of endogenous estrogen, sex hormone binding globulin and gonadotrophins. In the first two years of the current grant cycle it has been observed that feeding soy at a single dose alters plasma and urinary estrogen and gonadotrophin levels. More than a 30% decline in urinary estrogen excretion and a 20% decline in plasma estrogen level were noted upon feeding a soy drink. In this renewal application it is proposed to study the response of female sex hormone parameters to varying levels of orally administered isoflavonoids. These data will provide information that is necessary to evaluate the minimal dose of orally administered isoflavonoids required to achieve a significant and/or maximal effect on estrogen levels in plasma and urine. The amount of isoflavonoids excreted in the urine and the concentration plasma will also be studied to determine their response to the dose of isoflavanoids ingested orally. The relationship between urinary and plasma isoflavonoid concentration over a forty fold range of orally administered isoflavonoids will be evaluated to determine if urinary values can be used as a reliable indicator of plasma levels.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA054349-04
Application #
2095852
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1992-03-01
Project End
1999-01-31
Budget Start
1995-04-01
Budget End
1996-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Tufts University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
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Verma, S P; Goldin, B R; Lin, P S (1998) The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumin and isoflavonoids. Environ Health Perspect 106:807-12
Verma, S P; Salamone, E; Goldin, B (1997) Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem Biophys Res Commun 233:692-6
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Fairchild, R L; VanBuskirk, A M; Kondo, T et al. (1997) Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts. Transplantation 63:1807-12
Schaefer, E J; Lamon-Fava, S; Spiegelman, D et al. (1995) Changes in plasma lipoprotein concentrations and composition in response to a low-fat, high-fiber diet are associated with changes in serum estrogen concentrations in premenopausal women. Metabolism 44:749-56
Dwyer, J (1995) Overview: dietary approaches for reducing cardiovascular disease risks. J Nutr 125:656S-665S
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Dwyer, J T; Goldin, B R; Saul, N et al. (1994) Tofu and soy drinks contain phytoestrogens. J Am Diet Assoc 94:739-43
Goldin, B R; Gorbach, S L (1994) Hormone studies and the diet and breast cancer connection. Adv Exp Med Biol 364:35-46

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