Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA054557-01
Application #
3199123
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1991-03-15
Project End
1995-02-28
Budget Start
1991-03-15
Budget End
1992-02-29
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Madden, Charles R; Finegold, Milton J; Slagle, Betty L (2002) Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein. J Virol 76:11770-4
Madden, C R; Slagle, B L (2001) Stimulation of cellular proliferation by hepatitis B virus X protein. Dis Markers 17:153-7
Madden, C R; Finegold, M J; Slagle, B L (2001) Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J Virol 75:3851-8
Wentz, M J; Becker, S A; Slagle, B L (2000) Dissociation of DDB1-binding and transactivation properties of the hepatitis B virus X protein. Virus Res 68:87-92
Madden, C R; Finegold, M J; Slagle, B L (2000) Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice. J Virol 74:5266-72
Chomarat, P; Rice, J M; Slagle, B L et al. (1998) Hepatitis B virus-induced liver injury and altered expression of carcinogen metabolising enzymes: the role of the HBx protein. Toxicol Lett 102-103:595-601
Becker, S A; Lee, T H; Butel, J S et al. (1998) Hepatitis B virus X protein interferes with cellular DNA repair. J Virol 72:266-72
Sitterlin, D; Lee, T H; Prigent, S et al. (1997) Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants. J Virol 71:6194-9
Krishnamoorthy, R R; Lee, T H; Butel, J S et al. (1997) Apolipoprotein B gene regulatory factor-2 (BRF-2) is structurally and immunologically highly related to hepatitis B virus X associated protein-1 (XAP-1). Biochemistry 36:960-9
Slagle, B L; Lee, T H; Medina, D et al. (1996) Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog 15:261-9

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