Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA054786-03S1
Application #
3199318
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1991-09-01
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Cary, Leslie A; Klinghoffer, Richard A; Sachsenmaier, Christoph et al. (2002) SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading. Mol Cell Biol 22:2427-40
Sachsenmaier, C; Sadowski, H B; Cooper, J A (1999) STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation. Oncogene 18:3583-92
Klinghoffer, R A; Sachsenmaier, C; Cooper, J A et al. (1999) Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18:2459-71
Megidish, T; Cooper, J; Zhang, L et al. (1998) A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. J Biol Chem 273:21834-45
Gotoh, Y; Cooper, J A (1998) Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction. J Biol Chem 273:17477-82
Kawakami, Y; Hartman, S E; Holland, P M et al. (1998) Multiple signaling pathways for the activation of JNK in mast cells: involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7. J Immunol 161:1795-802
Winkler, D G; Cutler Jr, R E; Drugan, J K et al. (1998) Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity. J Biol Chem 273:21578-84
Winkler, D G; Johnson, J C; Cooper, J A et al. (1997) Identification and characterization of mutations in Ha-Ras that selectively decrease binding to cRaf-1. J Biol Chem 272:24402-9
Finch, A; Holland, P; Cooper, J et al. (1997) Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7. FEBS Lett 418:144-8
Chantry, D; Vojtek, A; Kashishian, A et al. (1997) p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem 272:19236-41

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