Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA055138-01S1
Application #
3199590
Study Section
Special Emphasis Panel (SRC (52))
Project Start
1991-08-15
Project End
1995-07-31
Budget Start
1991-08-15
Budget End
1992-07-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Cornell University
Department
Type
Schools of Engineering
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Roberts, S C; Naill, M; Gibson, D M et al. (2003) A simple method for enhancing paclitaxel release from Taxus canadensis cell suspension cultures utilizing cell wall digesting enzymes. Plant Cell Rep 21:1217-20
Ketchum, R E; Tandon, M; Gibson, D M et al. (1999) Isolation of labeled 9-dihydrobaccatin III and related taxoids from cell cultures of taxuscell cultures of taxus canadensis elicited with m. J Nat Prod 62:1395-8
Ketchum, R E; Gibson, D M; Croteau, R B et al. (1999) The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol Bioeng 62:97-105
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Mirjalili, N; Linden, J C (1996) Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: ethylene interaction and induction models. Biotechnol Prog 12:110-8
Hefner, J; Rubenstein, S M; Ketchum, R E et al. (1996) Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chem Biol 3:479-89
Srinivasan, V; Ciddi, V; Bringi, V et al. (1996) Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures. Biotechnol Prog 12:457-65
Taticek, R A; Lee, C W; Shuler, M L (1994) Large-scale insect and plant cell culture. Curr Opin Biotechnol 5:165-74