Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA055141-04A1
Application #
2096357
Study Section
Special Emphasis Panel (ZRG3-BNP (02))
Project Start
1993-01-01
Project End
2000-04-30
Budget Start
1996-07-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Bode, Claudia J; Gupta, Mohan L; Suprenant, Kathy A et al. (2003) The two alpha-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro. EMBO Rep 4:94-9
Bode, Claudia J; Gupta Jr, Mohan L; Reiff, Emily A et al. (2002) Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry 41:3870-4
Gupta Jr, Mohan L; Bode, Claudia J; Thrower, Douglas A et al. (2002) beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast. Mol Biol Cell 13:2919-32
Gupta Jr, M L; Bode, C J; Dougherty, C A et al. (2001) Mutagenesis of beta-tubulin cysteine residues in Saccharomyces cerevisiae: mutation of cysteine 354 results in cold-stable microtubules. Cell Motil Cytoskeleton 49:67-77
Chakrabarti, G; Mejillano, M R; Park, Y H et al. (2000) Nucleoside triphosphate specificity of tubulin. Biochemistry 39:10269-74
Panda, D; Chakrabarti, G; Hudson, J et al. (2000) Suppression of microtubule dynamic instability and treadmilling by deuterium oxide. Biochemistry 39:5075-81
Chakrabarti, G; Kim, S; Gupta Jr, M L et al. (1999) Stabilization of tubulin by deuterium oxide. Biochemistry 38:3067-72
Sengupta, S; Boge, T C; Liu, Y et al. (1997) Probing the environment of tubulin-bound paclitaxel using fluorescent paclitaxel analogues. Biochemistry 36:5179-84
Gupta, M L; Toso, R J; Farrell, K W et al. (1995) Commercial [3H]glutamate contains a contaminant that labels tubulin covalently. Anal Biochem 230:350-3
Sengupta, S; Boge, T C; Georg, G I et al. (1995) Interaction of a fluorescent paclitaxel analogue with tubulin. Biochemistry 34:11889-94

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