Germinal Center Interactions of Normal/Malignant B Cells

Freedman, Arnold S.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA055207-05
• Application #: 2096413
• Study Section: Pathology B Study Section (PTHB)
• Project Start: 1991-07-08
• Project End: 1999-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Dana-Farber Cancer Institute
• DUNS #: 149617367
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02215

Publications

Husson, Herve; Carideo, Elizabeth G; Neuberg, Donna et al. (2002) Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. Blood 99:282-9

Husson, H; Lugli, S M; Ghia, P et al. (2000) Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells. Cell Immunol 203:134-43

Grossbard, M L; Multani, P S; Freedman, A S et al. (1999) A Phase II study of adjuvant therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with relapsed B-cell non-Hodgkin's lymphoma. Clin Cancer Res 5:2392-8

Grossbard, M L; Fidias, P; Kinsella, J et al. (1998) Anti-B4-blocked ricin: a phase II trial of 7 day continuous infusion in patients with multiple myeloma. Br J Haematol 102:509-15

Ghia, P; Boussiotis, V A; Schultze, J L et al. (1998) Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood 91:244-51

Manie, S N; Sattler, M; Astier, A et al. (1997) Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation. Exp Hematol 25:45-50

Manie, S N; Astier, A; Haghayeghi, N et al. (1997) Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2. J Biol Chem 272:15636-41

Astier, A; Manie, S N; Law, S F et al. (1997) Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. Leuk Lymphoma 28:65-72

Astier, A; Avraham, H; Manie, S N et al. (1997) The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. J Biol Chem 272:228-32

Astier, A; Manie, S N; Avraham, H et al. (1997) The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1. J Biol Chem 272:19719-24