Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA055711-04A1
Application #
2096819
Study Section
Special Emphasis Panel (ZRG2-MEP (01))
Project Start
1992-03-01
Project End
2000-02-29
Budget Start
1996-05-15
Budget End
1997-02-28
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Burczynski, M E; Sridhar, G R; Palackal, N T et al. (2001) The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. J Biol Chem 276:2890-7
Burczynski, M E; Penning, T M (2000) Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor. Cancer Res 60:908-15
Penning, T M; Burczynski, M E; Hung, C F et al. (1999) Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. Chem Res Toxicol 12:1-18
Lin, H K; Hung, C F; Moore, M et al. (1999) Genomic structure of rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD, AKR1C9). J Steroid Biochem Mol Biol 71:29-39
Hung, C F; Penning, T M (1999) Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD AKR1C9) gene expression: a member of the aldo-keto reductase superfamily. Mol Endocrinol 13:1704-17
Burczynski, M E; Lin, H K; Penning, T M (1999) Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res 59:607-14
Hou, Y T; Lin, H K; Penning, T M (1998) Dexamethasone regulation of the rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase gene. Mol Pharmacol 53:459-66
Burczynski, M E; Harvey, R G; Penning, T M (1998) Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry 37:6781-90
Penning, T M (1997) Molecular endocrinology of hydroxysteroid dehydrogenases. Endocr Rev 18:281-305
Bennett, M J; Albert, R H; Jez, J M et al. (1997) Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Structure 5:799-812

Showing the most recent 10 out of 18 publications