Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA056115-02
Application #
3200614
Study Section
Special Emphasis Panel (SRC)
Project Start
1991-05-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Sampson, J H; Ashley, D M; Archer, G E et al. (1997) Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. Neurosurgery 41:1365-72; discussion 1372-3
Hare, C B; Elion, G B; Houghton, P J et al. (1997) Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol 39:187-91
Sampson, J H; Archer, G E; Ashley, D M et al. (1996) Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the ""immunologically privileged"" central nervous system. Proc Natl Acad Sci U S A 93:10399-404
Moynihan, K; Elion, G B; Ali-Osman, F et al. (1996) Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. Cancer Chemother Pharmacol 38:349-54
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Batra, S K; McLendon, R E; Koo, J S et al. (1995) Prognostic implications of chromosome 17p deletions in human medulloblastomas. J Neurooncol 24:39-45
Castellino, S M; Friedman, H S; Elion, G B et al. (1995) Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. Br J Cancer 71:1181-7
Reist, C J; Archer, G E; Kurpad, S N et al. (1995) Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. Cancer Res 55:4375-82
Kurpad, S N; Friedman, H S; Archer, G E et al. (1995) Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats. Cancer Res 55:3803-9

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