Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA056483-03
Application #
2097344
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1993-02-01
Project End
1995-03-31
Budget Start
1995-02-01
Budget End
1995-03-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Wong, N C; Mueller, B M; Barbas, C F et al. (1998) Alphav integrins mediate adhesion and migration of breast carcinoma cell lines. Clin Exp Metastasis 16:50-61
Smith, J W (1997) Allostery and proteolysis: two novel modes of regulating integrin function. Matrix Biol 16:173-8
Lin, E C; Ratnikov, B I; Tsai, P M et al. (1997) Evidence that the integrin beta3 and beta5 subunits contain a metal ion-dependent adhesion site-like motif but lack an I domain. J Biol Chem 272:14236-43
Lin, E C; Ratnikov, B I; Tsai, P M et al. (1997) Identification of a region in the integrin beta3 subunit that confers ligand binding specificity. J Biol Chem 272:23912-20
Seiffert, D; Smith, J W (1997) The cell adhesion domain in plasma vitronectin is cryptic. J Biol Chem 272:13705-10
Jongewaard, I N; Tsai, P M; Smith, J W (1996) The type III connecting segment of fibronectin contains an aspartic acid residue that regulates the rate of binding to integrin alpha 4 beta 1. Cell Adhes Commun 3:487-95
Hu, D D; Barbas, C F; Smith, J W (1996) An allosteric Ca2+ binding site on the beta3-integrins that regulates the dissociation rate for RGD ligands. J Biol Chem 271:21745-51
Stuiver, I; Ruggeri, Z; Smith, J W (1996) Divalent cations regulate the organization of integrins alpha v beta 3 and alpha v beta 5 on the cell surface. J Cell Physiol 168:521-31
Hu, D D; Hoyer, J R; Smith, J W (1995) Ca2+ suppresses cell adhesion to osteopontin by attenuating binding affinity for integrin alpha v beta 3. J Biol Chem 270:9917-25
Smith, J W; Tachias, K; Madison, E L (1995) Protein loop grafting to construct a variant of tissue-type plasminogen activator that binds platelet integrin alpha IIb beta 3. J Biol Chem 270:30486-90

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