Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA056564-01
Application #
2097386
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1992-08-01
Project End
1992-09-30
Budget Start
1992-08-01
Budget End
1992-09-30
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Adam, L; Bandyopadhyay, D; Kumar, R (2000) Interferon-alpha signaling promotes nucleus-to-cytoplasmic redistribution of p95Vav, and formation of a multisubunit complex involving Vav, Ku80, and Tyk2. Biochem Biophys Res Commun 267:692-6
Mandal, M; Bandyopadhyay, D; Goepfert, T M et al. (1998) Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK). Oncogene 16:217-25
Engelhardt, M; Kumar, R; Albanell, J et al. (1997) Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 90:182-93
Mandal, M; Maggirwar, S B; Sharma, N et al. (1996) Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. J Biol Chem 271:30354-9
Korutla, L; Kumar, R (1996) Inhibition of vesicular stomatitis virus replication by epidermal growth factor in human epidermoid A-431 cells. Biochem Biophys Res Commun 220:670-4
Zhu, X; Kumar, R; Mandal, M et al. (1996) Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc Natl Acad Sci U S A 93:6091-5
Korutla, L; Kumar, R (1996) Mechanism of interferon action: in vivo activation of 91 kDa transcription factor. Anticancer Res 16:2789-95
Kumar, R; Mandal, M; Ratzkin, B J et al. (1996) NDF induces expression of a novel 46 kD protein in estrogen receptor positive breast cancer cells. J Cell Biochem 62:102-12
Kumar, R; Korutla, L (1995) Growth inhibition of human acute promyelocytic leukemia NB-4 cells by interferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways. Anticancer Res 15:353-60
Kumar, R; Korutla, L (1995) Induction of expression of interferon-stimulated gene factor-3 (ISGF-3) proteins by interferons. Exp Cell Res 216:143-8

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