Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA056846-04
Application #
2097634
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1992-05-14
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Pathology
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Zhou, G; Kuo, M T (1998) Wild-type p53-mediated induction of rat mdr1b expression by the anticancer drug daunorubicin. J Biol Chem 273:15387-94
Priebe, W; Krawczyk, M; Kuo, M T et al. (1998) Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem Biophys Res Commun 247:859-63
Zhou, G; Kuo, M T (1997) NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J Biol Chem 272:15174-83
Zhou, G; Song, R; Kuo, M T (1996) A novel cis-acting element is involved in the promoter activity of the rat mdr1b gene. Cell Growth Differ 7:1369-81
Ishikawa, T; Bao, J J; Yamane, Y et al. (1996) Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. J Biol Chem 271:14981-8
Kuo, M T; Bao, J J; Curley, S A et al. (1996) Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Cancer Res 56:3642-4
Bao, J J; Zhang, W W; Kuo, M T (1996) Adenoviral delivery of recombinant DNA into transgenic mice bearing hepatocellular carcinomas. Hum Gene Ther 7:355-65
Kuo, M T; Julian, J; Husain, F et al. (1995) Regulation of multidrug resistance gene mdr1b/mdr1 expression in isolated mouse uterine epithelial cells. J Cell Physiol 164:132-41
Song, R; Ikeguchi, M; Zhou, G et al. (1995) Identification and characterization of a hepatoma cell-specific enhancer in the mouse multidrug resistance mdr1b promoter. J Biol Chem 270:25468-74
Zhao, J Y; Savaraj, N; Song, R et al. (1994) Overexpression of P-glycoprotein but not its mRNA in multidrug resistant cells selected with hydroxyrubicin. Anticancer Res 14:1735-42

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