We propose to conduct the first large case-control interview study of risk factors for childhood neuroblastoma. About 640 cases (under age 19 years at diagnosis) will be identified through the Childrens Cancer Study Group (CCSG) and the Pediatric Oncology Group (POG). Parents of cases and of 640 controls matched on age, sex, and race will be interviewed by telephone. Controls will be selected by random digit telephone dialing. The study will evaluate the relative importance of risk factors for neuroblastoma which were reported from previous studies. These include: maternal use of medications during pregnancy (specifically alcohol, diuretics and a group of drugs that includes amphetamines, antidepressants, antipsychotics and tranquilizers); parental employment in the electronics industry and occupational exposures to electromagnetic fields; maternal age at birth and subjects length of gestation and birth weight. The study will also evaluate drugs used by the mother during pregnancy for their potential to cause transplacental exposure of the fetus to N-nitroso compounds. Information on other potential risk factors such as family medical, gestational and delivery history will also be collected. It will examine the possibility of neuroblastoma having a similar set of risk factors in common with other childhood cancers. Since most of the patients have data collected on clinical, biologic and genetic markers, we will analyze the potential environmental risk factors separately for subgroups of patients defined by such characteristics as disease stage and N-myc oncogene amplification. This study can provide important new insights into the etiology of childhood cancer since neuroblastoma's pattern of occurrence in very early childhood suggests that parental or in utero exposures may play an important role in its etiology.
| Bunin, Greta R; Spector, Logan G; Olshan, Andrew F et al. (2007) Secular trends in response rates for controls selected by random digit dialing in childhood cancer studies: a report from the Children's Oncology Group. Am J Epidemiol 166:109-16 |
| Bluhm, Elizabeth C; Daniels, Julie; Pollock, Brad H et al. (2006) Maternal use of recreational drugs and neuroblastoma in offspring: a report from the Children's Oncology Group (United States). Cancer Causes Control 17:663-9 |
| McCall, Erin E; Olshan, Andrew F; Daniels, Julie L (2005) Maternal hair dye use and risk of neuroblastoma in offspring. Cancer Causes Control 16:743-8 |
| Menegaux, Florence; Olshan, Andrew F; Reitnauer, Pamela J et al. (2005) Positive association between congenital anomalies and risk of neuroblastoma. Pediatr Blood Cancer 45:649-55 |
| Menegaux, Florence; Olshan, Andrew F; Neglia, Joseph P et al. (2004) Day care, childhood infections, and risk of neuroblastoma. Am J Epidemiol 159:843-51 |
| Patton, Tara; Olshan, Andrew F; Neglia, Joseph P et al. (2004) Parental exposure to medical radiation and neuroblastoma in offspring. Paediatr Perinat Epidemiol 18:178-85 |
| Cook, Michael N; Olshan, Andrew F; Guess, Harry A et al. (2004) Maternal medication use and neuroblastoma in offspring. Am J Epidemiol 159:721-31 |
| Olshan, Andrew F; Smith, Joanna C; Bondy, Melissa L et al. (2002) Maternal vitamin use and reduced risk of neuroblastoma. Epidemiology 13:575-80 |
| Daniels, Julie L; Olshan, Andrew F; Pollock, Brad H et al. (2002) Breast-feeding and neuroblastoma, USA and Canada. Cancer Causes Control 13:401-5 |
| De Roos, A J; Poole, C; Teschke, K et al. (2001) An application of hierarchical regression in the investigation of multiple paternal occupational exposures and neuroblastoma in offspring. Am J Ind Med 39:477-86 |
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