The ets oncongene superfamily codes for a family of transcriptional factors of which some are involved in leukemias, lymphomas and sarcomas. Previously, we have identified and characterized a new member of this oncogene family elk-1. Recently, we have shown that elk-1 is a transcriptional activator which regulates c-fos oncogene activity. We plan to study the mechanism of activation of fos by elk-1 proteins, identify the natural targets and study the role in cell growth, differentiation, signal transduction and cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA057322-06
Application #
6032274
Study Section
Pathology B Study Section (PTHB)
Program Officer
Gallahan, Daniel L
Project Start
1995-06-01
Project End
2000-05-31
Budget Start
1998-11-11
Budget End
1999-05-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Mcp Hahnemann University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19102
Fortson, Wendell S; Kayarthodi, Shubhalaxmi; Fujimura, Yasuo et al. (2011) Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol 39:111-9
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Cui, J Q; Shao, N; Chai, Y et al. (1998) BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator. Oncol Rep 5:591-5
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