Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA057820-05
Application #
2098562
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1992-08-07
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1998-05-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Genetics
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kirii, Y; Magarian-Blander, J; Alter, M D et al. (1998) Functional and molecular analysis of T cell receptors used by pancreatic- and breast tumor- (mucin-) specific cytotoxic T cells. J Immunother 21:188-97
Henderson, R A; Konitsky, W M; Barratt-Boyes, S M et al. (1998) Retroviral expression of MUC-1 human tumor antigen with intact repeat structure and capacity to elicit immunity in vivo. J Immunother 21:247-56
Magarian-Blander, J; Ciborowski, P; Hsia, S et al. (1998) Intercellular and intracellular events following the MHC-unrestricted TCR recognition of a tumor-specific peptide epitope on the epithelial antigen MUC1. J Immunol 160:3111-20
Poland, P A; Kinlough, C L; Rokaw, M D et al. (1997) Differential glycosylation of MUC1 in tumors and transfected epithelial and lymphoblastoid cell lines. Glycoconj J 14:89-96
Barratt-Boyes, S M; Watkins, S C; Finn, O J (1997) Migration of cultured chimpanzee dendritic cells following intravenous and subcutaneous injection. Adv Exp Med Biol 417:71-5
Henderson, R A; Finn, O J (1996) Human tumor antigens are ready to fly. Adv Immunol 62:217-56
Magarian-Blander, J; Hughey, R P; Kinlough, C et al. (1996) Differential expression of MUC1 on transfected cell lines influences its recognition by MUC1 specific T cells. Glycoconj J 13:749-56
Finn, O J; Debruyne, L A; Bishop, D K (1996) T cell receptor (TCR) repertoire in alloimmune responses. Int Rev Immunol 13:187-207
Pecher, G; Finn, O J (1996) Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells. Proc Natl Acad Sci U S A 93:1699-704
Ciborowski, P; Finn, O J (1995) Recombinant epithelial cell mucin (MUC-1) expressed in baculovirus resembles antigenically tumor associated mucin, target for cancer immunotherapy. Biomed Pept Proteins Nucleic Acids 1:193-8

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