Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058343-11
Application #
6769613
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Cole, John S
Project Start
1993-08-10
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
11
Fiscal Year
2004
Total Cost
$391,315
Indirect Cost
Name
Dartmouth College
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Yzaguirre, Amanda D; de Bruijn, Marella F T R; Speck, Nancy A (2017) The Role of Runx1 in Embryonic Blood Cell Formation. Adv Exp Med Biol 962:47-64
Yzaguirre, Amanda D; Speck, Nancy A (2016) Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites. Dev Dyn 245:1011-28
Yzaguirre, Amanda D; Speck, Nancy A (2016) Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos. Dev Biol 415:111-121
Ditadi, Andrea; Sturgeon, Christopher M; Tober, Joanna et al. (2015) Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nat Cell Biol 17:580-91
Imanirad, Parisa; Solaimani Kartalaei, Parham; Crisan, Mihaela et al. (2014) HIF1? is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo. Stem Cell Res 12:24-35
de Pater, Emma; Kaimakis, Polynikis; Vink, Chris S et al. (2013) Gata2 is required for HSC generation and survival. J Exp Med 210:2843-50
Clarke, Raedun L; Yzaguirre, Amanda D; Yashiro-Ohtani, Yumi et al. (2013) The expression of Sox17 identifies and regulates haemogenic endothelium. Nat Cell Biol 15:502-10
Guo, Hong; Ma, Ou; Speck, Nancy A et al. (2012) Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis. Blood 119:4408-18
Yokomizo, Tomomasa; Yamada-Inagawa, Tomoko; Yzaguirre, Amanda D et al. (2012) Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos. Nat Protoc 7:421-31
Pajcini, K V; Speck, N A; Pear, W S (2011) Notch signaling in mammalian hematopoietic stem cells. Leukemia 25:1525-32

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