Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA058927-03
Application #
2099542
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1993-03-01
Project End
1997-12-31
Budget Start
1994-12-16
Budget End
1994-12-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Kagamu, H; Shu, S (1998) Purification of L-selectin(low) cells promotes the generation of highly potent CD4 antitumor effector T lymphocytes. J Immunol 160:3444-52
Liu, J; Finke, J; Krauss, J C et al. (1998) Ex vivo activation of tumor-draining lymph node T cells reverses defects in signal transduction molecules. Cancer Immunol Immunother 46:268-76
Plautz, G E; Touhalisky, J E; Shu, S (1997) Treatment of murine gliomas by adoptive transfer of ex vivo activated tumor-draining lymph node cells. Cell Immunol 178:101-7
Kagamu, H; Touhalisky, J E; Plautz, G E et al. (1996) Isolation based on L-selectin expression of immune effector T cells derived from tumor-draining lymph nodes. Cancer Res 56:4338-42
Inoue, M; Plautz, G E; Shu, S (1996) Treatment of intracranial tumors by systemic transfer of superantigen-activated tumor-draining lymph node T cells. Cancer Res 56:4702-8
Krauss, J C; Stein, J M; Shu, S (1996) Tumor reactivity of immune T cells in short-term culture. Cancer Immunol Immunother 43:231-9
Plautz, G E; Inoue, M; Shu, S (1996) Defining the synergistic effects of irradiation and T-cell immunotherapy for murine intracranial tumors. Cell Immunol 171:277-84
Sussman, J J; Wahl, W L; Chang, A E et al. (1995) Unique characteristics associated with systemic adoptive immunotherapy of experimental intracerebral tumors. J Immunother Emphasis Tumor Immunol 18:35-44
Aruga, A; Shu, S; Chang, A E (1995) Tumor-specific granulocyte/macrophage colony-stimulating factor and interferon gamma secretion is associated with in vivo therapeutic efficacy of activated tumor-draining lymph node cells. Cancer Immunol Immunother 41:317-24
Matsumura, T; Sussman, J J; Krinock, R A et al. (1994) Characteristics and in vivo homing of long-term T-cell lines and clones derived from tumor-draining lymph nodes. Cancer Res 54:2744-50

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