|
Zheng, Zhe-Bin; Zhu, Guozhang; Tak, Heekyung et al. (2005) N-(2-hydroxypropyl)methacrylamide copolymers of a glutathione (GSH)-activated glyoxalase i inhibitor and DNA alkylating agent: synthesis, reaction kinetics with GSH, and in vitro antitumor activities. Bioconjug Chem 16:598-607
|
|
Joseph, Erin; Ganem, Bruce; Eiseman, Julie L et al. (2005) Selective inhibition of MCF-7(piGST) breast tumors using glutathione transferase-derived 2-methylene-cycloalkenones. J Med Chem 48:6549-52
|
|
Zheng, Zhe-Bin; Creighton, Donald J (2003) Bivalent transition-state analogue inhibitors of human glyoxalase I. Org Lett 5:4855-8
|
|
Creighton, D J; Zheng, Z-B; Holewinski, R et al. (2003) Glyoxalase I inhibitors in cancer chemotherapy. Biochem Soc Trans 31:1378-82
|
|
Hamilton, Diana S; Zhang, Xiyun; Ding, Zhebo et al. (2003) Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts. J Am Chem Soc 125:15049-58
|
|
Hamilton, Diana S; Ding, Zhebo; Ganem, Bruce et al. (2002) Glutathionyl transferase catalyzed addition of glutathione to COMC: a new hypothesis for antitumor activity. Org Lett 4:1209-12
|
|
Huntley, C F; Hamilton, D S; Creighton, D J et al. (2000) Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor. Org Lett 2:3143-4
|
|
Kalsi, A; Kavarana, M J; Lu, T et al. (2000) Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem 43:3981-6
|
|
Sharkey, E M; O'Neill, H B; Kavarana, M J et al. (2000) Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I. Cancer Chemother Pharmacol 46:156-66
|
|
Kavarana, M J; Kovaleva, E G; Creighton, D J et al. (1999) Mechanism-based competitive inhibitors of glyoxalase I: intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum. J Med Chem 42:221-8
|
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