The overall goal of this project is to determine what factors affect the risk of recurrence and death in women diagnosed with breast cancer before age 45. This project builds on the information already collected on 1400 women who were diagnosed with invasive breast cancer before age 45 from 1983 - 1992 and interviewed about risk factors for disease. This cohort will be followed for recurrence and mortality through December, 1996. These women represent the majority (85%) of incident cases from these years in King, Pierce, and Snohomish Counties in Washington State. From within this cohort, all women with recurrence and/or death will be identified. These women will be compared to women from within the cohort without recurrence and/or death on the following factors: 1. Patient characteristics and risk factors collected in the detailed interview such as oral contraceptive use, history of induced abortion, and other reproductive factors, family history of breast cancer, mammography history, obesity, etc. 2. Timing of surgery in relation to the menstrual cycle. 3. Histopathologic characteristics including histologic type, generalized nuclear grade, number of mitoses, size, multicentricity, location, clinical presentation, lymph node metastases, and status of margins of the tumors as determined by pathologic review. 4. Expression of tumor-related proteins by immunocytochemistry, including steroid receptors, oncogene proteins, p53 tumor suppressor gene product, growth factors, and proliferating cell nuclear antigen (PCNA). 5. Evidence of angiogenic response determined by image analysis quantification of vascular density and mRNA expression of angiogenesis-related factors. 6. Cell proliferation and aneuploidy determined by flow cytometric analysis of S-phase fraction and DNA content of formalin-fixed, paraffin-embedded tumor. In addition, we will evaluate the relationship(s) of patient characteristics and exposure data (1 and 2 above) to tumor characteristics (3 - 6 above) at diagnosis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA059736-03
Application #
2100339
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1993-06-05
Project End
1998-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Malone, Kathleen E; Daling, Janet R; Doody, David R et al. (2011) Family history of breast cancer in relation to tumor characteristics and mortality in a population-based study of young women with invasive breast cancer. Cancer Epidemiol Biomarkers Prev 20:2560-71
Madeleine, Margaret M; Johnson, Lisa G; Malkki, Mari et al. (2011) Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer. Breast Cancer Res Treat 129:887-99
Reding, Kerryn W; Daling, Janet R; Doody, David R et al. (2008) Effect of prediagnostic alcohol consumption on survival after breast cancer in young women. Cancer Epidemiol Biomarkers Prev 17:1988-96
Sanderson, Maureen; Daling, Janet R; Doody, David R et al. (2006) Perinatal factors and mortality from breast cancer. Cancer Epidemiol Biomarkers Prev 15:1984-7
Friedrichsen, Danielle M; Malone, Kathleen E; Doody, David R et al. (2004) Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women. Breast Cancer Res 6:R629-35
Suter, Nicola M; Malone, Kathleen E; Daling, Janet R et al. (2003) Androgen receptor (CAG)n and (GGC)n polymorphisms and breast cancer risk in a population-based case-control study of young women. Cancer Epidemiol Biomarkers Prev 12:127-35
Li, C I; Malone, K E; Porter, P L et al. (2003) Epidemiologic and molecular risk factors for contralateral breast cancer among young women. Br J Cancer 89:513-8
Daling, Janet R; Malone, Kathleen E; Doody, David R et al. (2002) The relation of reproductive factors to mortality from breast cancer. Cancer Epidemiol Biomarkers Prev 11:235-41
Daling, J R; Malone, K E; Doody, D R et al. (2001) Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma. Cancer 92:720-9
Sanderson, M; Williams, M A; White, E et al. (1998) Validity and reliability of subject and mother reporting of perinatal factors. Am J Epidemiol 147:136-40

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