Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA059926-03
Application #
2100537
Study Section
Pathology A Study Section (PTHA)
Project Start
1994-02-15
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Rininsland, F; Johnson, T R; Chernicky, C L et al. (1997) Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells. Proc Natl Acad Sci U S A 94:5854-9
Shevelev, A; Burfeind, P; Schulze, E et al. (1997) Potential triple helix-mediated inhibition of IGF-I gene expression significantly reduces tumorigenicity of glioblastoma in an animal model. Cancer Gene Ther 4:105-12
Chernicky, C L; Tan, H; Burfeind, P et al. (1996) Sequence of interleukin-2 isolated from human placental poly A+ RNA: possible role in maintenance of fetal allograft. Mol Reprod Dev 43:180-6
Burfeind, P; Chernicky, C L; Rininsland, F et al. (1996) Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc Natl Acad Sci U S A 93:7263-8
Trojan, J; Naval, X; Johnson, T et al. (1995) Expression of serum albumin and of alphafetoprotein in murine normal and neoplastic primitive embryonic structures. Mol Reprod Dev 42:369-78
Lamande, N; Brosset, S; Lucas, M et al. (1995) Transcriptional up-regulation of the mouse gene for the muscle-specific subunit of enolase during terminal differentiation of myogenic cells. Mol Reprod Dev 41:306-13
Trojan, J; Johnson, T R; Rudin, S D et al. (1994) Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation. Proc Natl Acad Sci U S A 91:6088-92