Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA059958-03
Application #
2100568
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1994-01-14
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pathology
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Ding, Qiang; Grammer, J Robert; Nelson, Mark A et al. (2005) p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. J Biol Chem 280:6802-15
Hecker, Timothy P; Ding, Qiang; Rege, Tanya A et al. (2004) Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene 23:3962-71
Repovic, Pavle; Fears, Constance Y; Gladson, Candece L et al. (2003) Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells. Oncogene 22:8117-24
Ding, Qiang; Stewart Jr, Jerry; Olman, Mitchell A et al. (2003) The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged. J Biol Chem 278:39882-91
Natarajan, Meera; Hecker, Timothy P; Gladson, Candece L (2003) FAK signaling in anaplastic astrocytoma and glioblastoma tumors. Cancer J 9:126-33
Hecker, Timothy P; Grammer, J Robert; Gillespie, G Yancey et al. (2002) Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples. Cancer Res 62:2699-707
Ding, Qiang; Stewart Jr, Jerry; Prince, Charles W et al. (2002) Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin. Cancer Res 62:5336-43
Han, X; Stewart Jr, J E; Bellis, S L et al. (2001) TGF-beta1 up-regulates paxillin protein expression in malignant astrocytoma cells: requirement for a fibronectin substrate. Oncogene 20:7976-86
Wang, D; Grammer, J R; Cobbs, C S et al. (2000) p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo. J Cell Sci 113 Pt 23:4221-30
Gladson, C L; Stewart, J E; Olman, M A et al. (2000) Attachment of primary neonatal rat astrocytes to vitronectin is mediated by integrins alphavbeta5 and alpha8beta1: modulation by the type 1 plasminogen activator inhibitor. Neurosci Lett 283:157-61

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