Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060592-03
Application #
2101337
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1994-05-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Genetics
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Cao, J P; Meyn, M S; Eckardt-Schupp, F et al. (2001) TEL1 from Saccharomyces cerevisiae suppresses chromosome aberrations induced by ionizing radiation in ataxia-telangiectasia cells without affecting cell cycle checkpoints. Radiat Environ Biophys 40:309-15
Fritz, E; Friedl, A A; Zwacka, R M et al. (2000) The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells. Mol Biol Cell 11:2605-16
Uhrhammer, N; Fritz, E; Boyden, L et al. (1999) Human fibroblasts transfected with an ATM antisense vector respond abnormally to ionizing radiation. Int J Mol Med 4:43-7
Meyn, M S (1999) Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene. Clin Genet 55:289-304
Elsea, S H; Fritz, E; Schoener-Scott, R et al. (1998) Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity. Am J Med Genet 75:104-8
Fritz, E; Elsea, S H; Patel, P I et al. (1997) Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype. Proc Natl Acad Sci U S A 94:4538-42
Xu, Y; Ashley, T; Brainerd, E E et al. (1996) Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10:2411-22
Keegan, K S; Holtzman, D A; Plug, A W et al. (1996) The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev 10:2423-37