Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA061242-03
Application #
2101974
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-06-01
Project End
1997-07-24
Budget Start
1996-09-01
Budget End
1997-07-24
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Carbone, David P; Ciernik, I Frank; Kelley, Michael J et al. (2005) Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome. J Clin Oncol 23:5099-107
Almand, B; Resser, J R; Lindman, B et al. (2000) Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res 6:1755-66
Ciernik, I F; Romero, P; Berzofsky, J A et al. (1999) Ionizing radiation enhances immunogenicity of cells expressing a tumor-specific T-cell epitope. Int J Radiat Oncol Biol Phys 45:735-41
Ishida, T; Chada, S; Stipanov, M et al. (1999) Dendritic cells transduced with wild-type p53 gene elicit potent anti-tumour immune responses. Clin Exp Immunol 117:244-51
Oyama, T; Ran, S; Ishida, T et al. (1998) Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol 160:1224-32
Gabrilovich, D I; Corak, J; Ciernik, I F et al. (1997) Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res 3:483-90
Ciernik, I F; Berzofsky, J A; Carbone, D P (1996) Human lung cancer cells endogenously expressing mutant p53 process and present the mutant epitope and are lysed by mutant-specific cytotoxic T lymphocytes. Clin Cancer Res 2:877-82
Gabrilovich, D I; Ciernik, I F; Carbone, D P (1996) Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts. Cell Immunol 170:101-10
Gabrilovich, D I; Chen, H L; Girgis, K R et al. (1996) Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 2:1096-103