Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061764-04
Application #
2102538
Study Section
Special Emphasis Panel (SRC (70))
Project Start
1994-02-15
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1998-01-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai Medical Center
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Wolff, Nicholas C; Randle, Dwight E; Egorin, Merrill J et al. (2004) Imatinib mesylate efficiently achieves therapeutic intratumor concentrations in vivo but has limited activity in a xenograft model of small cell lung cancer. Clin Cancer Res 10:3528-34
Wolff, Nicholas C; Richardson, James A; Egorin, Merrill et al. (2003) The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia. Blood 101:5010-3
Wolff, N C; Ilaria Jr, R L (2001) Establishment of a murine model for therapy-treated chronic myelogenous leukemia using the tyrosine kinase inhibitor STI571. Blood 98:2808-16
Wang, Y; Rosenstein, B; Goldwyn, S et al. (1998) Differential regulation of P53 and Bcl-2 expression by ultraviolet A and B. J Invest Dermatol 111:380-4
Wang, Y; Zhang, X; Lebwohl, M et al. (1998) Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein. Carcinogenesis 19:649-54
Brown, A; Jolly, P; Wei, H (1998) Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kinase activity and N-myc expression. Carcinogenesis 19:991-7
Wei, H; Bowen, R; Zhang, X et al. (1998) Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogenesis 19:1509-14
Wei, H; Ca, Q; Rahn, R et al. (1998) DNA structural integrity and base composition affect ultraviolet light-induced oxidative DNA damage. Biochemistry 37:6485-90
Wei, H; Cai, Q; Tian, L et al. (1998) Tamoxifen reduces endogenous and UV light-induced oxidative damage to DNA, lipid and protein in vitro and in vivo. Carcinogenesis 19:1013-8
Zhang, X; Rosenstein, B S; Wang, Y et al. (1997) Identification of possible reactive oxygen species involved in ultraviolet radiation-induced oxidative DNA damage. Free Radic Biol Med 23:980-5

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