Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061879-02
Application #
2102720
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1995-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Guthrie Foundation for Education and Research
Department
Type
DUNS #
City
Sayre
State
PA
Country
United States
Zip Code
18840
Chang, N S (2001) Hyaluronidase activation of c-Jun N-terminal kinase is necessary for protection of L929 fibrosarcoma cells from staurosporine-mediated cell death. Biochem Biophys Res Commun 283:278-86
Chang, N S; Pratt, N; Heath, J et al. (2001) Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem 276:3361-70
Cao, H; Pratt, N; Mattison, J et al. (2000) Characterization of an apoptosis inhibitory domain at the C-termini of FE65-like protein. Biochem Biophys Res Commun 276:843-50
Chang, N S (2000) TGF-beta-induced matrix proteins inhibit p42/44 MAPK and JNK activation and suppress TNF-mediated IkappaBalpha degradation and NF-kappaB nuclear translocation in L929 fibroblasts. Biochem Biophys Res Commun 267:194-200
Chang, N S; Mattison, J; Cao, H et al. (1998) Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity. Biochem Biophys Res Commun 253:743-9
Chang, N S (1998) Transforming growth factor-beta protection of cancer cells against tumor necrosis factor cytotoxicity is counteracted by hyaluronidase (review). Int J Mol Med 2:653-9
Chang, N S (1997) Hyaluronidase enhancement of TNF-mediated cell death is reversed by TGF-beta 1. Am J Physiol 273:C1987-94
Chang, N S (1995) Transforming growth factor-beta 1 induction of novel extracellular matrix proteins that trigger resistance to tumor necrosis factor cytotoxicity in murine L929 fibroblasts. J Biol Chem 270:7765-72
Chang, N S (1995) Hyaluronidase induces murine L929 fibrosarcoma cells resistant to tumor necrosis factor and Fas cytotoxicity in the presence of actinomycin D. Cell Biochem Biophys 27:109-32