Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063193-03
Application #
2104910
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1994-05-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Desai, Amar; Webb, Bryan; Gerson, Stanton L (2014) CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells. Radiother Oncol 110:538-45
Qing, Yulan; Wang, Zhengqi; Bunting, Kevin D et al. (2014) Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence. Blood 123:1002-11
Qing, Yulan; Lin, Yuan; Gerson, Stanton L (2012) An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood 119:1768-71
Kisby, G E; Olivas, A; Park, T et al. (2009) DNA repair modulates the vulnerability of the developing brain to alkylating agents. DNA Repair (Amst) 8:400-12
Liu, Lili; Gerson, Stanton L (2006) Targeted modulation of MGMT: clinical implications. Clin Cancer Res 12:328-31
Vollweiler, J L; Zielske, S P; Reese, J S et al. (2003) Hematopoietic stem cell gene therapy: progress toward therapeutic targets. Bone Marrow Transplant 32:1-7
Reese, Jane S; Liu, Lili; Gerson, Stanton L (2003) Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood 102:1626-33
Bowman, Janice E; Reese, Jane S; Lingas, Karen T et al. (2003) Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. Mol Ther 8:42-50
Gerson, Stanton L (2002) Clinical relevance of MGMT in the treatment of cancer. J Clin Oncol 20:2388-99
Zhou, Hang; Liu, Lili; Lee, Keunmyoung et al. (2002) Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea. Oncogene 21:8732-40

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