Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063218-02
Application #
2104943
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1995-07-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Xia, Jie; Xue, Jun; Locke, Robert D et al. (2006) Synthesis of fluorinated mucin core 2 branched oligosaccharides with the potential of novel substrates and enzyme inhibitors for glycosyltransferases and sulfotransferases. J Org Chem 71:3696-706
Xia, Jie; Alderfer, James L; Locke, Robert D et al. (2003) Complex oligosaccharide investigations: synthesis of an octasaccharide incorporating the dimeric Le(x) structure of PSGL-1. J Org Chem 68:2752-9
Xia, Jie; Alderfer, James L; Srikrishnan, Thamarapu et al. (2002) A convergent synthesis of core 2 branched sialylated and sulfated oligosaccharides. Bioorg Med Chem 10:3673-84
Neelamegham, Sriram; Matta, Khushi L (2002) Liposomes containing ligands. Binding specificity to selectins. Methods Mol Biol 199:175-91
Xia, J; Alderfer, J L; Piskorz, C F et al. (2001) The 2-naphthylmethyl (NAP) group in carbohydrate synthesis: first total synthesis of the GlyCAM-1 oligosaccharide structures. Chemistry 7:356-67
Xia, J; Alderfer, J L; Piskorz, C F et al. (2000) Total synthesis of sialylated and sulfated oligosaccharide chains from respiratory mucins. Chemistry 6:3442-51
Xia, J; Alderfer, J L; Matta, K L (2000) Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group. Bioorg Med Chem Lett 10:2485-7
Xia, J; Alderfer, J L; Piskorz, C F et al. (2000) A convergent synthesis of trisaccharides with alpha-Neu5Ac-(2 --> 3)-beta-D-gal-(1 --> 4)-beta-D-GlcNAc and alpha-Neu5Ac-(2 --> 3)-beta-D-gal-(1 --> 3)-alpha-D-GalNAc sequences. Carbohydr Res 328:147-63
Chandrasekaran, E V; Jain, R K; Rhodes, J M et al. (1999) Characterization of distinct Gal:3-O-sulfotransferase activities in human tumor epithelial cell lines and of calf lymph node GlcNAc : 6-O-sulfotransferase activity. Glycoconj J 16:523-36
Xia, J; Piskorz, C F; Locke, R D et al. (1999) An efficient synthesis of two monosulfated trisaccharides with the Galbeta1,3GlcNacbeta1,3Galbeta-O-allyl backbone. Bioorg Med Chem Lett 9:2941-6

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