Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064416-04
Application #
2414335
Study Section
Pathology A Study Section (PTHA)
Project Start
1994-07-01
Project End
1999-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Dentistry
Type
Schools of Dentistry
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Polverini, Peter J; Nor, Jacques E; Peters, Martin C et al. (2003) Growth of human blood vessels in severe combined immunodeficient mice. A new in vivo model system of angiogenesis. Methods Mol Med 78:161-77
Lane, Brian R; Liu, Jianguo; Bock, Paul J et al. (2002) Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma. J Virol 76:11570-83
Nor, J E; Peters, M C; Christensen, J B et al. (2001) Engineering and characterization of functional human microvessels in immunodeficient mice. Lab Invest 81:453-63
Nor, J E; Mitra, R S; Sutorik, M M et al. (2000) Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway. J Vasc Res 37:209-18
Foreman, K E; Wrone-Smith, T; Krueger, A E et al. (1999) Expression of costimulatory molecules CD80 and/or CD86 by a Kaposi's sarcoma tumor cell line induces differential T-cell activation and proliferation. Clin Immunol 91:345-53
Nor, J E; Christensen, J; Mooney, D J et al. (1999) Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 154:375-84
Polverini, P J; Nor, J E (1999) Apoptosis and predisposition to oral cancer. Crit Rev Oral Biol Med 10:139-52
Nissen, N N; Polverini, P J; Koch, A E et al. (1998) Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol 152:1445-52
Foreman, K E; Alkan, S; Krueger, A E et al. (1998) Geographically distinct HHV-8 DNA sequences in Saudi Arabian Iatrogenic Kaposi's sarcoma lesions. Am J Pathol 153:1001-4
Lamszus, K; Jin, L; Fuchs, A et al. (1997) Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice. Lab Invest 76:339-53

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