Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA065527-01A2
Application #
2108542
Study Section
Pathology B Study Section (PTHB)
Project Start
1996-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Biology
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Kim, M P; Park, S I; Kopetz, S et al. (2009) Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis. Cell Tissue Res 335:249-59
Herynk, Matthew H; Zhang, Jing; Parikh, Nila U et al. (2007) Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells. J Exp Ther Oncol 6:205-17
Trevino, Jose G; Gray, Michael J; Nawrocki, Steffan T et al. (2006) Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells. Angiogenesis 9:101-10
Trevino, Jose G; Summy, Justin M; Lesslie, Donald P et al. (2006) Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. Am J Pathol 168:962-72
Gray, Michael J; Wey, Jane S; Belcheva, Anna et al. (2005) Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors. Cancer Res 65:3664-70
Trevino, Jose G; Summy, Justin M; Gray, Michael J et al. (2005) Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Res 65:7214-22
Gray, Michael J; Zhang, Jing; Ellis, Lee M et al. (2005) HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 24:3110-20
Kim, Sun Jin; Johnson, Marjorie; Koterba, Kristen et al. (2003) Reduced c-Met expression by an adenovirus expressing a c-Met ribozyme inhibits tumorigenic growth and lymph node metastases of PC3-LN4 prostate tumor cells in an orthotopic nude mouse model. Clin Cancer Res 9:5161-70
Herynk, Matthew H; Stoeltzing, Oliver; Reinmuth, Niels et al. (2003) Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells. Cancer Res 63:2990-6
Summy, Justin M; Gallick, Gary E (2003) Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 22:337-58

Showing the most recent 10 out of 24 publications