Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA065878-01A1
Application #
2109048
Study Section
Special Emphasis Panel (ZRG7-SSS-6 (08))
Project Start
1996-03-01
Project End
1997-01-31
Budget Start
1996-03-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Blair, I A (2001) Lipid hydroperoxide-mediated DNA damage. Exp Gerontol 36:1473-81
Lee, S H; Blair, I A (2001) Oxidative DNA damage and cardiovascular disease. Trends Cardiovasc Med 11:148-55
Lee, S H; Oe, T; Blair, I A (2001) Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 292:2083-6
Lee, S H; Blair, I A (2000) Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol 13:698-702
Lee, S H; Rindgen, D; Bible Jr, R H et al. (2000) Characterization of 2'-deoxyadenosine adducts derived from 4-oxo-2-nonenal, a novel product of lipid peroxidation. Chem Res Toxicol 13:565-74
Rindgen, D; Lee, S H; Nakajima, M et al. (2000) Formation of a substituted 1,N(6)-etheno-2'-deoxyadenosine adduct by lipid hydroperoxide-mediated generation of 4-oxo-2-nonenal. Chem Res Toxicol 13:846-52
Singh, G; Gutierrez, A; Xu, K et al. (2000) Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range. Anal Chem 72:3007-13
McCoull, K D; Rindgen, D; Blair, I A et al. (1999) Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts. Chem Res Toxicol 12:237-46
Rindgen, D; Nakajima, M; Wehrli, S et al. (1999) Covalent modifications to 2'-deoxyguanosine by 4-oxo-2-nonenal, a novel product of lipid peroxidation. Chem Res Toxicol 12:1195-204
Felix, C A; Walker, A H; Lange, B J et al. (1998) Association of CYP3A4 genotype with treatment-related leukemia. Proc Natl Acad Sci U S A 95:13176-81