Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA066029-02
Application #
2109252
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1995-06-10
Project End
2000-03-31
Budget Start
1996-08-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Ezquerra, Laura; Herradon, Gonzalo; Nguyen, Trang et al. (2006) Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta. Life Sci 79:1049-55
Perez-Pinera, P; Alcantara, S; Dimitrov, T et al. (2006) Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition. Proc Natl Acad Sci U S A 103:17795-800
Zhang, Nan; Zhong, Rong; Perez-Pinera, Pablo et al. (2006) Identification of the angiogenesis signaling domain in pleiotrophin defines a mechanism of the angiogenic switch. Biochem Biophys Res Commun 343:653-8
Christman, Karen L; Fang, Qizhi; Kim, Anne J et al. (2005) Pleiotrophin induces formation of functional neovasculature in vivo. Biochem Biophys Res Commun 332:1146-52
Ezquerra, Laura; Herradon, Gonzalo; Nguyen, Trang et al. (2005) Midkine, a newly discovered regulator of the renin-angiotensin pathway in mouse aorta: significance of the pleiotrophin/midkine developmental gene family in angiotensin II signaling. Biochem Biophys Res Commun 333:636-43
Herradon, Gonzalo; Ezquerra, Laura; Nguyen, Trang et al. (2005) Midkine regulates pleiotrophin organ-specific gene expression: evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family. Biochem Biophys Res Commun 333:714-21
Pariser, Harold; Ezquerra, Laura; Herradon, Gonzalo et al. (2005) Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin. Biochem Biophys Res Commun 332:664-9
Pariser, Harold; Perez-Pinera, Pablo; Ezquerra, Laura et al. (2005) Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta. Biochem Biophys Res Commun 335:232-9
Wang, Zhaoyi; Zhang, Xintian; Shen, Peng et al. (2005) Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66. Biochem Biophys Res Commun 336:1023-7
Pariser, Harold; Herradon, Gonzalo; Ezquerra, Laura et al. (2005) Pleiotrophin regulates serine phosphorylation and the cellular distribution of beta-adducin through activation of protein kinase C. Proc Natl Acad Sci U S A 102:12407-12

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