Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA066725-01A1
Application #
2110175
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1996-02-09
Project End
2000-11-30
Budget Start
1996-02-09
Budget End
1996-11-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kearney, Kathleen E; Pretlow, Thomas G; Pretlow, Theresa P (2009) Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. Int J Cancer 125:249-52
Luo, Liping; Shen, Gong-Qing; Stiffler, Karen A et al. (2006) Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer. Carcinogenesis 27:1153-9
Pretlow, Theresa P; Pretlow, Thomas G (2005) Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer? Biochim Biophys Acta 1756:83-96
Luo, Liping; Chen, Wei-dong; Pretlow, Theresa P (2005) CpG island methylation in aberrant crypt foci and cancers from the same patients. Int J Cancer 115:747-51
Chen, Wei-Dong; Han, Z James; Skoletsky, Joel et al. (2005) Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst 97:1124-32
Pretlow, Theresa P; Edelmann, Winfried; Kucherlapati, Raju et al. (2003) Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele. Am J Pathol 163:1757-63
Luo, Liping; Li, Biaoru; Pretlow, Theresa P (2003) DNA alterations in human aberrant crypt foci and colon cancers by random primed polymerase chain reaction. Cancer Res 63:6166-9
Li, Hui; Myeroff, Lois; Smiraglia, Dominic et al. (2003) SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A 100:8412-7
Hardy, R G; Tselepis, C; Hoyland, J et al. (2002) Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut 50:513-9
Hao, X P; Pretlow, T G; Rao, J S et al. (2001) Inducible nitric oxide synthase (iNOS) is expressed similarly in multiple aberrant crypt foci and colorectal tumors from the same patients. Cancer Res 61:419-22

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