We propose to develop and evaluate Magnetic Resonance Imaging (MRI) pulse sequences to detect breast cancer and distinguish it from benign breast disease; and to develop and evaluate MRI-guided biopsy techniques. We will develop and optimize a new, ultra-fast spiral k- space MR pulse sequence that has fat suppression, magnetization transfer, and high resolution, and evaluate it with a pharmokinetic model. We will also optimize an existing high resolution three- dimensional spectral-spatial volume acquisition magnetization transfer (3DSSMT) pulse sequence. MR-compatible biopsy techniques with 14- gauge large core needles will be developed, and MR scan techniques for interactively guiding needle placement optimized. We will study 120 women with the optimized 3DSSMT and dynamic spiral k-space MR sequences to identify and characterize enhancing breast lesions. All lesions will be core biopsied with MRI guidance, a wire placed, and pathology confirmed by surgical excision of the wire localized lesion. We will use receiver operating characteristic (ROC) curves to measure the ability of the new MR technique to detect focal and multicentric breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA066785-03
Application #
2895257
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Program Officer
Menkens, Anne E
Project Start
1997-08-01
Project End
2001-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Horst, Kathleen C; Fero, Katherine E; Hancock, Steven L et al. (2016) Breast Imaging in Women Previously Irradiated for Hodgkin Lymphoma. Am J Clin Oncol 39:114-9
Kurian, Allison W; Munoz, Diego F; Rust, Peter et al. (2012) Online tool to guide decisions for BRCA1/2 mutation carriers. J Clin Oncol 30:497-506
Kurian, Allison W; Sigal, Bronislava M; Plevritis, Sylvia K (2010) Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers. J Clin Oncol 28:222-31
van de Ven, Stephanie M W Y; Lin, Margaret C; Daniel, Bruce L et al. (2010) Freehand MRI-guided preoperative needle localization of breast lesions after MRI-guided vacuum-assisted core needle biopsy without marker placement. J Magn Reson Imaging 32:101-9
Han, Misung; Beatty, Philip J; Daniel, Bruce L et al. (2009) Independent slab-phase modulation combined with parallel imaging in bilateral breast MRI. Magn Reson Med 62:1221-31
Han, Misung; Daniel, Bruce L; Hargreaves, Brian A (2008) Accelerated bilateral dynamic contrast-enhanced 3D spiral breast MRI using TSENSE. J Magn Reson Imaging 28:1425-34
Kurian, Allison W; Hartman, Anne-Renee; Mills, Meredith A et al. (2008) Magnetic resonance galactography: a feasibility study in women with prior atypical breast duct cytology. Breast J 14:211-4
Hargreaves, Brian A; Cunningham, Charles H; Pauly, John M et al. (2007) Independent phase modulation for efficient dual-band 3D imaging. Magn Reson Med 57:798-802
Vidarsson, Logi; Cunningham, Charles; Gold, Garry E et al. (2007) T2-selective magnetization preparation pulses. IEEE Trans Med Imaging 26:981-9
Po, Julia; Margolis, Daniel J A; Cunningham, Charles H et al. (2006) Water-selective spectral-spatial contrast-enhanced breast MRI for cancer detection in patients with extracapsular and injected free silicone. Magn Reson Imaging 24:1363-7

Showing the most recent 10 out of 23 publications