The investigator proposes a model and means for studying hypoxia/ischemia protective interventions. Oxygen levels, phosphate metabolites and cerebral blood flow will be studied in experiments that are as parallel as the measurements allow. The problems in making the different measurements at the same time were handled well in the introduction to the revised application. This is a revised application proposing the use of NMR and EPR to probe metabolic parameters related to ischemic and hypoxic brain.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA067431-01A2
Application #
2008860
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Jacobs, Tom P
Project Start
1997-07-01
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
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Hou, Huagang; Grinberg, Oleg Y; Taie, Satoshi et al. (2003) Electron paramagnetic resonance assessment of brain tissue oxygen tension in anesthetized rats. Anesth Analg 96:1467-72, table of contents
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Rolett, E L; Azzawi, A; Liu, K J et al. (2000) Critical oxygen tension in rat brain: a combined (31)P-NMR and EPR oximetry study. Am J Physiol Regul Integr Comp Physiol 279:R9-R16
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