Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA067888-10
Application #
2111688
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1986-08-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Yu, J; Baron, V; Mercola, D et al. (2007) A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death Differ 14:436-46
Baron, V; Adamson, E D; Calogero, A et al. (2006) The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther 13:115-24
Adamson, Eileen D; Yu, Jianxiu; Mustelin, Tomas (2005) Co-factors p300 and CBP catch Egr1 in their network. Prostate 63:407-10
Subauste, M Cecilia; Nalbant, Perihan; Adamson, Eileen D et al. (2005) Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. J Biol Chem 280:5676-81
Krones-Herzig, Anja; Mittal, Shalu; Yule, Kelly et al. (2005) Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res 65:5133-43
Subauste, M Cecilia; Pertz, Olivier; Adamson, Eileen D et al. (2004) Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol 165:371-81
Hayakawa, Jun; Mittal, Shalu; Wang, Yipeng et al. (2004) Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell 16:521-35
Yu, Jianxiu; de Belle, Ian; Liang, Hongyan et al. (2004) Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell 15:83-94
Adamson, Eileen; de Belle, Ian; Mittal, Shalu et al. (2003) Egr1 signaling in prostate cancer. Cancer Biol Ther 2:617-22
Krones-Herzig, Anja; Adamson, Eileen; Mercola, Dan (2003) Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proc Natl Acad Sci U S A 100:3233-8

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