Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA069331-01A1
Application #
2113414
Study Section
Pathology B Study Section (PTHB)
Project Start
1996-08-15
Project End
1999-07-31
Budget Start
1996-08-15
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Uemura, Y; Pak, S C; Luke, C et al. (2000) Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Int J Cancer 89:368-77
Luke, C; Schick, C; Tsu, C et al. (2000) Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. Biochemistry 39:7081-91
Cataltepe, S; Gornstein, E R; Schick, C et al. (2000) Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. J Histochem Cytochem 48:113-22
Cataltepe, S; Schick, C; Luke, C J et al. (2000) Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2. Clin Chim Acta 295:107-27
Amemiya, C T; Zhong, T P; Silverman, G A et al. (1999) Zebrafish YAC, BAC, and PAC genomic libraries. Methods Cell Biol 60:235-58
Bartuski, A J; Kamachi, Y; Schick, C et al. (1998) A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Genomics 54:297-306
Silverman, G A; Bartuski, A J; Cataltepe, S et al. (1998) SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3. Tumour Biol 19:480-7
Schick, C; Bromme, D; Bartuski, A J et al. (1998) The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition. Proc Natl Acad Sci U S A 95:13465-70
Zeng, W; Silverman, G A; Remold-O'Donnell, E (1998) Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. Gene 213:179-87
Schick, C; Pemberton, P A; Shi, G P et al. (1998) Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry 37:5258-66

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