. The primary prevention of breast cancer is an important public health goal in this country. Exercise has been associated with a decreased risk for breast cancer. One mechanism may be via a hormonal pathway. Exercise decreases body fat, especially abdominal fat, which may be the mechanism through which exercise could lower concentrations of endogenous estrogens in premenopausal women. This application is a randomized interventional study that will test the effect of a one-year, moderate intensity exercise program on androgenous sex hormone profile in postmenopausal woman. Women (N=168) who are age 55-75 years will be randomized to either a one-year, moderate intensity exercise program or a controlled program of no change in exercise habits. Dietary intake will be assessed at baseline and follow-up through four-day food records. Serum hormones will be assayed at baseline and at end-of-study. These hormones include: total estrone, total estradiol, free estradiol, percent bioavailable estradiol, estrone sulfate, sex hormone binding globulin, albumin, testosterone, free testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, insulin, glucose and triglycerides. The ratio of urinary 2-hydroxyestrone (2-OHE1) to 16a-hydroxyestrone (16-alpha-E1), an estrogen metabolite ratio which may be associated with breast cancer, will also be assayed at baseline and at end-of-study. The effect of exercise on weight, body mass index, total fat mass, and body fat distribution will also be assessed. This study plans to give insight into possible mechanisms through which exercise may be associated with decreased risk of breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA069334-02
Application #
2700653
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Patel, Appasaheb1 R
Project Start
1997-08-13
Project End
2001-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Spector, June T; De Roos, Anneclaire J; Ulrich, Cornelia M et al. (2014) Plasma polychlorinated biphenyl concentrations and immune function in postmenopausal women. Environ Res 131:174-80
Duggan, Catherine; Xiao, Liren; Wang, Ching-Yun et al. (2014) Effect of a 12-month exercise intervention on serum biomarkers of angiogenesis in postmenopausal women: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 23:648-57
Ulrich, Cornelia M; Toriola, Adetunji T; Koepl, Lisel M et al. (2012) Metabolic, hormonal and immunological associations with global DNA methylation among postmenopausal women. Epigenetics 7:1020-8
Williams, Lori; Ulrich, Cornelia M; Larson, Timothy et al. (2011) Fine particulate matter (PM?.?) air pollution and immune status among women in the Seattle area. Arch Environ Occup Health 66:155-65
Campbell, Peter T; Gross, Myron D; Potter, John D et al. (2010) Effect of exercise on oxidative stress: a 12-month randomized, controlled trial. Med Sci Sports Exerc 42:1448-53
Hooper, Laura E; Foster-Schubert, Karen E; Weigle, David S et al. (2010) Frequent intentional weight loss is associated with higher ghrelin and lower glucose and androgen levels in postmenopausal women. Nutr Res 30:163-70
Williams, Lori A; Ulrich, Cornelia M; Larson, Timothy et al. (2009) Proximity to traffic, inflammation, and immune function among women in the Seattle, Washington, area. Environ Health Perspect 117:373-8
Kong, Angela; Neuhouser, Marian L; Xiao, Liren et al. (2009) Higher habitual intake of dietary fat and carbohydrates are associated with lower leptin and higher ghrelin concentrations in overweight and obese postmenopausal women with elevated insulin levels. Nutr Res 29:768-76
Campbell, Peter T; Campbell, Kristin L; Wener, Mark H et al. (2009) A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc 41:1533-9
Meyers, Julie A; Liu, Amy Y; McTiernan, Anne et al. (2008) Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women. J Endocrinol 199:51-60

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