Abstract

This is a competing continuation application for continued study of human papilloma virus (HPV) genital persistent in a large cohort of low income women in Sao Paolo, Brazil, a high risk area for cervical carcinoma. The study focuses on the relationship of oncogenic HPV types on the development of cervical epithelial lesions and carcinoma. Participants undergo a series of questionnaire-based interviews to access sexual behavior and other potentially contributing factors, PAP smears, HPV testing by PCR, HPV serology and cervicography. The objectives are to 1 study incidence and prevalence of persistent cervical HPV in asymptomatic women; 2 verify the hypothesis that persistent HPV increases low and high grade cervical lesions; 3 detect epidemiological determinants of HPV persistence; 4 search for molecular variants associated with cervical lesions; 5 to determine whether HPV viral load is associated with persistence, and low or high grade lesions; and 6 study the role of antibody response to HPV persistence and lesion progression. For the competitive renewal, 2 additional aims are proposed: 7 identity HLA haplotypes associated with HPV persistence and cervical lesions; and 8 test whether p53 polymorphisms confer resistance to HPV persistence and lesion development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA070269-04
Application #
2859162
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Starks, Vaurice
Project Start
1996-09-11
Project End
2002-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mcgill University
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
H3 0-G4

  Publications

Sichero, Laura; El-Zein, Mariam; Nunes, Emily M et al. (2017) Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses. Cancer Epidemiol Biomarkers Prev 26:1312-1320
Tota, Joseph E; Ramanakumar, Agnihotram V; Villa, Luisa L et al. (2016) Cervical Infection With Vaccine-Associated Human Papillomavirus (HPV) Genotypes as a Predictor of Acquisition and Clearance of Other HPV Infections. J Infect Dis 214:676-84
Shaw, Eileen; Ramanakumar, Agnihotram V; El-Zein, Mariam et al. (2016) Reproductive and genital health and risk of cervical human papillomavirus infection: results from the Ludwig-McGill cohort study. BMC Infect Dis 16:116
El-Zein, Mariam; Richardson, Lyndsay; Franco, Eduardo L (2016) Cervical cancer screening of HPV vaccinated populations: Cytology, molecular testing, both or none. J Clin Virol 76 Suppl 1:S62-S68
Trottier, Helen; Mayrand, Marie-Hélène; Baggio, Maria Luiza et al. (2015) Risk of Human Papillomavirus (HPV) Infection and Cervical Neoplasia after Pregnancy. BMC Pregnancy Childbirth 15:244
Tota, Joseph E; Ramanakumar, Agnihotram V; Villa, Luisa L et al. (2015) Evaluation of human papillomavirus type replacement postvaccination must account for diagnostic artifacts: masking of HPV52 by HPV16 in anogenital specimens. Cancer Epidemiol Biomarkers Prev 24:286-90
de Araujo-Souza, Patrícia S; Ramanakumar, Agnihotram V; Candeias, João M G et al. (2014) Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study. BMC Infect Dis 14:578
Trevisan, Andrea; Schlecht, Nicolas F; Ramanakumar, Agnihotram V et al. (2013) Human papillomavirus type 16 viral load measurement as a predictor of infection clearance. J Gen Virol 94:1850-7
Walter, Stephen D; Riddell, Corinne A; Rabachini, Tatiana et al. (2013) Accuracy of p53 codon 72 polymorphism status determined by multiple laboratory methods: a latent class model analysis. PLoS One 8:e56430
Tota, Joseph E; Ramanakumar, Agnihotram V; Mahmud, Salaheddin M et al. (2013) Cervical human papillomavirus detection is not affected by menstrual phase. Sex Transm Infect 89:202-6

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