Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA070414-01
Application #
2114306
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1996-05-10
Project End
2001-04-30
Budget Start
1996-05-10
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Gurley, Kay E; Ashley, Amanda K; Moser, Russell D et al. (2017) Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation. Cell Death Differ 24:1853-1860
Moser, Russell; Toyoshima, Masafumi; Robinson, Kristin et al. (2012) MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency. Mol Cancer Res 10:535-45
Busch, Stephanie E; Gurley, Kay E; Moser, Russell D et al. (2012) ARF suppresses hepatic vascular neoplasia in a carcinogen-exposed murine model. J Pathol 227:298-305
Grosse-Wilde, Anne; Kemp, Christopher J (2008) Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans? Cancer Res 68:6035-7
Bailey, S Lawrence; Gurley, Kay E; Hoon-Kim, Kyung et al. (2008) Tumor suppression by p53 in the absence of Atm. Mol Cancer Res 6:1185-92
Grosse-Wilde, Anne; Voloshanenko, Oksana; Bailey, S Lawrence et al. (2008) TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest 118:100-10
Gurley, Kay E; Kemp, Christopher J (2007) Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues. Mol Cancer Res 5:1312-8
Kemp, Christopher J (2005) Multistep skin cancer in mice as a model to study the evolution of cancer cells. Semin Cancer Biol 15:460-73
Philipp-Staheli, Jeannette; Kim, Kyung-Hoon; Liggitt, Denny et al. (2004) Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development. Oncogene 23:905-13
Gurley, K E; Vo, K; Kemp, C J (1998) DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice. Cancer Res 58:3111-5

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