Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA071560-01
Application #
2115153
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1996-07-10
Project End
1999-06-30
Budget Start
1996-07-10
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Nasertorabi, Fariborz; Tars, Kaspars; Becherer, Kathleen et al. (2006) Molecular basis for regulation of Src by the docking protein p130Cas. J Mol Recognit 19:30-8
Briknarova, Klara; Nasertorabi, Fariborz; Havert, Marnie L et al. (2005) The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle. J Biol Chem 280:21908-14
Nasertorabi, Fariborz; Alonso, Andres; Rogers, Scott W et al. (2005) Crystallization of the SH2-binding site of p130Cas in complex with Lck, a Src-family kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun 61:174-7
Nasertorabi, Fariborz; Garcia-Guzman, Miguel; Briknarova, Klara et al. (2004) Organization of functional domains in the docking protein p130Cas. Biochem Biophys Res Commun 324:993-8
Abassi, Yama A; Vuori, Kristiina (2002) Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. EMBO J 21:4571-82
Aoudjit, F; Vuori, K (2001) Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol 152:633-43
Garcia-Guzman, M; Larsen, E; Vuori, K (2000) The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk. Oncogene 19:4058-65
Aoudjit, F; Vuori, K (2000) Engagement of the alpha2beta1 integrin inhibits Fas ligand expression and activation-induced cell death in T cells in a focal adhesion kinase-dependent manner. Blood 95:2044-51
Garcia-Guzman, M; Dolfi, F; Zeh, K et al. (1999) Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation. Oncogene 18:7775-86
Blaukat, A; Ivankovic-Dikic, I; Gronroos, E et al. (1999) Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J Biol Chem 274:14893-901

Showing the most recent 10 out of 16 publications