Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA071851-01
Application #
2115375
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Pathology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Fan, Weimin; Sui, Meihua; Huang, Yi (2004) Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: mechanisms and its clinical impact. Curr Med Chem 11:403-11
Huang, Yi; Fan, Weimin (2002) IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines. Mol Pharmacol 61:105-13
Fu, L W; Deng, Z A; Pan, Q C et al. (2001) Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Anticancer Res 21:2273-80
Huang, Y; Johnson, K R; Norris, J S et al. (2000) Nuclear factor-kappaB/IkappaB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 60:4426-32
Zeng, S; Chen, Y Z; Fu, L et al. (2000) In vitro evaluation of schedule-dependent interactions between docetaxel and doxorubicin against human breast and ovarian cancer cells. Clin Cancer Res 6:3766-73
Fan, W (1999) Possible mechanisms of paclitaxel-induced apoptosis. Biochem Pharmacol 57:1215-21
Miller 3rd, M C; Johnson, K R; Willingham, M C et al. (1999) Apoptotic cell death induced by baccatin III, a precursor of paclitaxel, may occur without G(2)/M arrest. Cancer Chemother Pharmacol 44:444-52
Schandl, C A; Li, S; Re, G G et al. (1999) Mitotic chromosomal bcl-2. I. Stable expression throughout the cell cycle and association with isolated chromosomes. J Histochem Cytochem 47:139-49
Schandl, C A; Li, S; Re, G G et al. (1999) Mitotic chromosomal bcl-2. II. Localization to interphase nuclei. J Histochem Cytochem 47:151-8
Johnson, K R; Young, K K; Fan, W (1999) Antagonistic interplay between antimitotic and G1-S arresting agents observed in experimental combination therapy. Clin Cancer Res 5:2559-65

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