Abstract

The experiments in this application are designed to test the hypothesis that: 1. Cyclin C associates with proteins involved in cell cycle control including novel cdk's, """"""""pocket proteins"""""""" such as p130, and as yet undefined proteins; and 2. Cyclin C's associations with these proteins help govern cell cycle progression. To test these hypotheses, it is proposed to: (a) identify cyclin C associated proteins; (b) examine cyclin C's association with p130; and (c) test activities of cyclin C associated proteins.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA072573-04
Application #
6173309
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Spalholz, Barbara A
Project Start
1997-08-01
Project End
2002-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
4
Fiscal Year
2000
Total Cost
$137,587
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Ren, Shengjun; Rollins, Barrett J (2004) Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell 117:239-51
Shapiro, G I; Koestner, D A; Matranga, C B et al. (1999) Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines. Clin Cancer Res 5:2925-38
Shapiro, G I; Edwards, C D; Ewen, M E et al. (1998) p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol 18:378-87