Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA072823-02S2
Application #
2657886
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1996-06-01
Project End
1999-05-31
Budget Start
1997-06-01
Budget End
1998-05-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pathology
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Sham, S W Simon; McDonald, Jay M; Micoli, Keith J et al. (2008) Solution structure of a calmodulin-binding domain in the carboxy-terminal region of HIV type 1 gp160. AIDS Res Hum Retroviruses 24:607-16
Micoli, Keith J; Mamaeva, Olga; Piller, Sabine C et al. (2006) Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication. Virology 344:468-79
Ahn, Eun-Young; Pan, George; Vickers, Selwyn M et al. (2002) IFN-gammaupregulates apoptosis-related molecules and enhances Fas-mediated apoptosis in human cholangiocarcinoma. Int J Cancer 100:445-51
Radding, W; Williams, J P; McKenna, M A et al. (2000) Calmodulin and HIV type 1: interactions with Gag and Gag products. AIDS Res Hum Retroviruses 16:1519-25
Micoli, K J; Pan, G; Wu, Y et al. (2000) Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. J Biol Chem 275:1233-40
Pan, G; Vickers, S M; Pickens, A et al. (1999) Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin. Am J Pathol 155:193-203
Pan, G; Zhou, T; Radding, W et al. (1998) Calmodulin antagonists inhibit apoptosis of CD4+ T-cells from patients with AIDS. Immunopharmacology 40:91-103