Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA075028-06
Application #
6693778
Study Section
Chemical Pathology Study Section (CPA)
Program Officer
Poland, Alan P
Project Start
1999-01-13
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
6
Fiscal Year
2004
Total Cost
$359,550
Indirect Cost

  Institution

Name
Fox Chase Cancer Center
Department
Type
DUNS #
073724262
City
Philadelphia
State
PA
Country
United States
Zip Code
19111

  Publications

Bassi, Daniel E; Cenna, Jonathan; Zhang, Jirong et al. (2015) Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6). Mol Carcinog 54:1122-31
Bassi, Daniel E; Zhang, Jirong; Cenna, Jonathan et al. (2010) Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. Neoplasia 12:516-26
Page, Robert E; Klein-Szanto, Andres J P; Litwin, Samuel et al. (2007) Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer. Cell Oncol 29:289-99
de Cicco, Ricardo Lopez; Bassi, Daniel E; Benavides, Fernando et al. (2007) Inhibition of proprotein convertases: approaches to block squamous carcinoma development and progression. Mol Carcinog 46:654-9
Lopez de Cicco, Ricardo; Bassi, Daniel E; Zucker, Stanley et al. (2005) Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res 65:4162-71
Bassi, Daniel E; Fu, Jian; Lopez de Cicco, Ricardo et al. (2005) Proprotein convertases: ""master switches"" in the regulation of tumor growth and progression. Mol Carcinog 44:151-61
Bassi, Daniel E; Lopez De Cicco, Ricardo; Cenna, Jonathan et al. (2005) PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. Cancer Res 65:7310-9
Lopez de Cicco, Ricardo; Watson, James C; Bassi, Daniel E et al. (2004) Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. Clin Cancer Res 10:4480-8
Mahloogi, Haleh; Gonzalez-Guerrico, Anatilde M; Lopez De Cicco, Ricardo et al. (2003) Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells. Cancer Res 63:4997-5004
Grille, Sylvia Julien; Bellacosa, Alfonso; Upson, John et al. (2003) The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 63:2172-8

Showing the most recent 10 out of 16 publications