Kaposi's sarcoma (KS) is a multifocal complex tumor associated with AIDS. A new human herpesvirus (KSHV) has recently been linked to KS and the demonstration that viral sequences can be found in prostate tissue suggests that KSHV can be transmitted sexually. The objectives of this proposal are to use in situ hybridization and PCR to detect KSHV genes in tissues of HIV-infected and uninfected individuals so that the potential pathways of transmission, tissue reservoirs and the relationship between productive KSHV infection to the development of KS can be determined.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA075172-02
Application #
2700759
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Cremer, Kenneth J
Project Start
1997-07-15
Project End
2001-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455